Name | β-Apo-13-carotenone |
Synonyms | D'Orenone β-Apo-13-carotenone Β-APO-13-CAROTENONE 3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E,5E,7E)- |
CAS | 17974-57-1 |
Molecular Formula | C18H26O |
Molar Mass | 258.4 |
Density | 0.945±0.06 g/cm3(Predicted) |
Boling Point | 120 °C(Press: 0.0004 Torr) |
Solubility | DMSO |
Storage Condition | -20℃ |
In vitro study | β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene in homogenates of intestinal mucosa of rat. β-apo-13-carotenone is found to antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD. The uptake and/or metabolism of β-apo-13-carotenone does not allow for accumulation of these β-carotene metabolites in cells. 3T3-L1 adipocyte marker gene expression is induced by β-apo-carotenoid treatment. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.87 ml | 19.35 ml | 38.7 ml |
5 mM | 0.774 ml | 3.87 ml | 7.74 ml |
10 mM | 0.387 ml | 1.935 ml | 3.87 ml |
5 mM | 0.077 ml | 0.387 ml | 0.774 ml |